Pleural effusion nursing: Light's criteria, thoracentesis care, and re-expansion risk

A pleural effusion is an abnormal accumulation of fluid in the pleural space – the cavity between the visceral and parietal pleura surrounding the lung. Under normal conditions, only 10–20 mL of fluid occupies this space, providing lubrication during breathing. When fluid accumulates beyond this, it compresses lung tissue, impairs ventilation, and causes dyspnea. Pleural effusions are common across medical, surgical, cardiac, and oncology settings, making them essential knowledge for nursing students at every level.

The two fundamental categories – transudative and exudative – have different causes, different diagnostic findings, and different management pathways. Correctly distinguishing them guides everything from which labs to collect to which treatment the physician will order. This reference covers pathophysiology, causes by type, diagnostic workup including Light’s criteria, nursing assessment, thoracentesis care, and NCLEX-style practice questions.

Pair this page with the pneumonia nursing reference, pulmonary embolism nursing reference, and ARDS nursing reference – pleural effusions frequently co-occur with all three.

Pathophysiology

The pleural space is a potential space – normally only a thin film of fluid exists between the two pleural layers. Fluid enters via capillary filtration from the parietal pleural vessels and drains through lymphatic channels. Pleural effusion occurs when this balance is disrupted by one of two mechanisms.

Increased hydrostatic pressure or decreased oncotic pressure drives fluid out of the capillaries and into the pleural space without inflammation or protein leak. The resulting fluid has low protein content – it is essentially an ultrafiltrate of plasma. This is a transudative effusion. Conditions that raise venous hydrostatic pressure (such as heart failure) or reduce plasma oncotic pressure (such as hypoalbuminemia in cirrhosis or nephrotic syndrome) produce transudates.

Inflammation, infection, or disruption of the pleural surface increases capillary permeability, allowing protein, cells, and cellular debris to leak into the pleural space. The resulting fluid is protein-rich and cellular – an exudative effusion. Pneumonia, malignancy, tuberculosis, and pulmonary embolism all produce exudates through this mechanism.

This distinction is clinically essential because transudates are managed by treating the underlying hemodynamic problem (e.g., diuresis in heart failure), while exudates require specific treatment targeting the inflammatory cause (e.g., antibiotics for parapneumonic effusion, oncologic treatment for malignant effusion).

Etiology

Key distinctions to know for NCLEX:

• Congestive heart failure is the most common cause of pleural effusion overall and by far the most common cause of bilateral effusions. When effusions are unequal, the right side is often larger. The mechanism is elevated pulmonary venous and hydrostatic pressure – classic transudate. The 2023 BTS guideline suggests serum NT-proBNP to support a heart failure diagnosis when a unilateral effusion is suspected to be cardiac.
• Parapneumonic effusion develops in 20–40% of patients hospitalized with pneumonia. Uncomplicated parapneumonic effusions resolve with antibiotics; complicated effusions (pleural fluid pH 7.2 or lower, low glucose, positive Gram stain or culture, or frank pus) need chest tube drainage.
• Malignant effusion is an exudate caused by tumor involvement of the pleural surface, lymphatic obstruction, or direct tumor secretion. Common malignancies: lung cancer, breast cancer, and lymphoma. Recurrent malignant effusions are managed with tunneled pleural catheters or pleurodesis.
• Pulmonary embolism is one of the leading causes of exudative effusion – the effusion is usually small and unilateral. The mechanism involves pleural ischemia from impaired perfusion and inflammatory mediator release. See the pulmonary embolism nursing reference for full PE management.
• Hepatic cirrhosis produces a hepatic hydrothorax via movement of ascitic fluid through diaphragmatic defects into the pleural space (usually right-sided). It is a transudate.

Clinical presentation

Small effusions are often asymptomatic and detected incidentally on imaging. As fluid volume increases, symptoms become apparent.

Respiratory symptoms:

• Dyspnea – the most common presenting symptom; ranges from exertional dyspnea to dyspnea at rest depending on volume and rate of accumulation
• Pleuritic chest pain – sharp, localized, worsens with inspiration and coughing; typically present in the early inflammatory phase but often subsides once fluid accumulates and separates the inflamed pleural surfaces
• Non-productive cough – from compression of adjacent lung parenchyma
• Orthopnea – may occur with large bilateral effusions

Physical examination findings:

• Decreased or absent breath sounds over the affected area – hallmark finding; fluid dampens transmission of breath sounds to the chest wall
• Dullness to percussion – fluid is dense compared to air-filled lung; percussion over an effusion produces a dull (not resonant) note
• Decreased tactile fremitus – vibration transmitted through the chest wall is reduced when fluid is between the lung and the chest wall
• Egophony – “E to A” change at the upper border of the effusion; where the compressed lung lies above the fluid, a spoken “E” sounds like “A” on auscultation
• Tracheal deviation – may be present with massive effusions, deviating toward the unaffected side
• Decreased chest expansion – on the affected side

Diagnostic workup

Chest X-ray

The standard chest X-ray (PA view) is typically the first imaging obtained. Key findings:

• Blunting of the costophrenic angle – the earliest finding on the PA view, where a meniscus becomes visible at about 200 mL of fluid. The normally sharp angle between the diaphragm and chest wall becomes blunted
• Meniscus sign – the classic concave upper border of a pleural effusion, curving upward toward the lateral chest wall
• Opacification – larger effusions produce increasing opacification (white-out) of the lower lung field
• Tracheal deviation – away from the effusion in very large effusions

The lateral view is more sensitive: in Blackmore’s CT-correlated study, a meniscus appeared at the posterior costophrenic angle at about 50 mL, and at about 500 mL the meniscus obscured the hemidiaphragm. A lateral decubitus film can show small amounts of free fluid that the frontal view misses.

Limitations: Supine CXR (common in ICU patients) shows effusions as a diffuse haziness over the entire hemithorax rather than a discrete collection – making them easy to miss or confuse with infiltrates.

CT chest

CT scan is more sensitive than plain CXR and picks up small effusions the radiograph misses. CT also characterizes the pleural space (loculations, pleural thickening, pleural masses) and the underlying lung, which guides the decision about whether thoracentesis is needed and whether image guidance is required.

Ultrasound

Bedside thoracic ultrasound is more sensitive than CXR for small effusions and also shows loculations and septations. The 2023 BTS guidance says ultrasound should be performed at initial presentation and whenever a pleural procedure is done, and that it must be used for pleural aspiration. Clinical examination alone picks inaccurate puncture sites (Diacon 2003), and in a meta-analysis of 24 studies ultrasound guidance cut the odds of post-thoracentesis pneumothorax by about 70% (odds ratio 0.3).

Thoracentesis and pleural fluid analysis

Thoracentesis – needle aspiration of pleural fluid – is the definitive diagnostic procedure. Fluid is sent for a standard panel of tests:

Light’s criteria

Light’s criteria, first described by Dr. Richard Light in 1972, remain the clinical standard for distinguishing transudative from exudative effusions. The criteria require simultaneous serum and pleural fluid samples.

An effusion is exudative if it meets ANY ONE of the following:

If none of the three criteria are met, the effusion is classified as a transudate.

Clinical pearl – the misclassification problem: Light’s criteria are nearly 100% sensitive for exudates, but about 20% of patients with a heart failure effusion meet exudate criteria after receiving diuretics. When clinical suspicion for heart failure is high but the fluid meets exudate criteria by a narrow margin, the serum-minus-pleural-fluid gradients act as a corrective step: a protein gradient above 3.1 g/dL or an albumin gradient above 1.2 g/dL points to a true transudate. Neither gradient should replace Light’s criteria as the primary test, because on their own they misclassify a significant number of exudates.

Nursing assessment

Respiratory assessment priorities

• Breath sounds: Auscultate all lung fields bilaterally. Document decreased or absent sounds over the affected area and the level at which sounds diminish. Reassess after any intervention.
• Respiratory rate and effort: Note rate, depth, accessory muscle use, nasal flaring, subcostal retractions, and pursed-lip breathing
• Oxygen saturation: Continuous SpO2 monitoring; report sustained SpO2 below 94% (or per provider parameters) and any acute drops
• Percussion: Assess for dullness over the lower lung fields on the affected side
• Chest symmetry and expansion: Compare bilateral expansion; decreased expansion on the affected side
• Cough: Frequency and character (productive vs. non-productive)

Comfort assessment

• Pain: Use a validated pain scale; characterize quality (sharp, pleuritic vs. dull, pressure), location, and whether it changes with position or breathing
• Position of comfort: Many patients with pleural effusion prefer sitting upright or leaning slightly forward – this maximizes use of the unaffected lung and reduces dyspnea
• Activity tolerance: Note when dyspnea begins with exertion; use for goal-setting and discharge planning

Hemodynamic and systemic assessment

• Vital signs including temperature (fever suggests infectious etiology)
• Peripheral edema, jugular venous distension, and S3 gallop (suggest CHF as underlying cause)
• Liver enlargement or ascites (suggest hepatic cirrhosis)
• Weight (daily weights help track fluid status in cardiac and hepatic patients)

Nursing interventions

Why good lung down works

The governing principle in unilateral lung disease is “good lung down.” Gravity sends the larger share of pulmonary blood flow to whichever lung is dependent. If the diseased lung is placed dependent, that blood perfuses alveoli compressed by fluid and unable to participate in gas exchange, which widens the shunt and drops oxygenation. Placing the healthy lung dependent aligns the bulk of perfusion with the lung that is ventilating.

Sonnenblick and colleagues measured this directly in patients with unilateral pleural fluid and no parenchymal disease: mean PaO2 was 71.9 mmHg with the effusion uppermost versus 66.7 mmHg with the effusion dependent. The same logic underlies prone positioning in ARDS – redirect blood flow toward lung units that can still exchange gas.

Two airway situations invert the rule. Massive hemoptysis and a large lung abscess both call for the affected side down, because keeping the diseased lung dependent stops blood or pus draining through the bronchi into the healthy lung, and protecting the good lung from contamination outweighs the oxygenation gain. A pleural effusion or empyema sits outside the airway, so it carries no such spillage risk unless a bronchopleural fistula connects the two.

Thoracentesis nursing care

Thoracentesis is the procedure most directly managed by bedside nursing. It involves insertion of a needle or catheter through the chest wall into the pleural space to drain fluid.

Pre-procedure preparation

1. Informed consent – confirm signed consent is obtained; reinforce patient education on the procedure, positioning, and expected sensations
2. Positioning – the standard position is the patient sitting upright on the edge of the bed, leaning forward over a bedside table with arms resting on a pillow. This position widens the intercostal spaces posteriorly, opens the pleural space, and drops the diaphragm – maximizing access for the physician or proceduralist. Alternatively, the patient may straddle the chair backward and lean forward on a pillow resting on the chair back
3. Baseline vital signs – document respiratory rate, SpO2, blood pressure, and heart rate before the procedure
4. IV access – confirm patent IV access in case of emergent medications
5. Ultrasound marking – coordinate with provider for real-time or marked ultrasound guidance
6. Anticoagulants and labs – report anticoagulant and antiplatelet medications to the proceduralist and confirm any coagulation studies (INR, platelet count) that were ordered. In a 9,320-procedure series, bleeding occurred in 0.18% of thoracenteses and was not associated with INR, PTT, or platelet count (Ault 2015), so the decision to hold drugs or correct values belongs to the proceduralist
7. Explain what to expect – the patient will feel pressure and possibly a brief sharp sensation when local anesthetic is injected; instruct them not to cough or move during needle insertion

During the procedure

• Maintain the patient in the correct position throughout; steady patients who may shift
• Monitor SpO2 and respiratory status continuously
• Observe for signs of vasovagal reaction (bradycardia, diaphoresis, pallor, hypotension) – common in anxious or older patients
• Note the color and character of fluid being drained (straw-yellow = typical; bloody = hemothorax or malignancy; cloudy/purulent = empyema; milky = chylothorax)
• Monitor volume drained – the BTS 2023 clinical statement advises that, in general, no more than 1.5 L (1,500 mL) be drained in one attempt, and that the procedure stop earlier if chest tightness, pain, persistent cough, or worsening breathlessness develops. Drainage should be slow (syringe or gravity); vacuum bottles and wall suction are not recommended

Post-procedure monitoring

Post-thoracentesis nursing monitoring is a high-yield area for NCLEX and clinical practice.

Pneumothorax is the most common complication. A meta-analysis of 24 studies (6,605 thoracenteses) found an overall rate of 6.0%, with about a third of those pneumothoraces needing a chest tube; ultrasound guidance lowered the risk, while therapeutic taps and mechanical ventilation raised it (Gordon 2010). A single-center series of 9,320 procedures reported 0.61%, with risk rising when more than 1,500 mL was removed or more than one needle pass was needed (Ault 2015). Pneumothorax can come from puncture of the lung, air entering through the aspiration device, or a non-expandable lung that cannot re-expand once fluid is removed.

Signs to monitor for:

• Sudden onset or worsening dyspnea
• Ipsilateral sharp chest pain
• Decreased or absent breath sounds on the affected side (now absent where they were present before)
• Falling SpO2
• Tracheal deviation (in tension pneumothorax – a medical emergency)

Post-procedure protocol:

• Vital signs and SpO2 per facility protocol, commonly every 15 minutes for the first hour
• Chest X-ray when indicated: the 2023 BTS clinical statement advises a CXR if symptoms do not settle promptly, the procedure was complicated, or multiple attempts were needed, and says a routine CXR is not required after a straightforward procedure in an asymptomatic patient. Many US facilities still order one routinely, so follow the provider’s order
• Assess breath sounds bilaterally and compare to pre-procedure baseline
• Instruct the patient to report any sudden worsening of breathing, chest pain, or lightheadedness

Other complications to monitor:

• Reexpansion pulmonary edema – presents as cough, dyspnea, hypoxemia, and frothy sputum after drainage, usually within the first hour, classically when a lung collapsed for a prolonged period reexpands abruptly. Report immediately. Symptomatic cases occur in fewer than 1% of thoracenteses (BTS 2023). The evidence on volume limits is debated: Feller-Kopman and colleagues found clinical RPE in 1 of 185 large-volume taps (0.5%) and no association with volume removed, pleural pressure, or pleural elastance, and argued that large effusions can be drained completely unless chest discomfort develops or end-expiratory pleural pressure falls below -20 cm H2O. The 2023 BTS clinical statement remains conservative because RPE can be fatal: in general a maximum of 1.5 L per attempt, with larger volumes only under monitoring by expert teams, and it found that routine pleural manometry does not reduce the risk. The 1,500 mL limit is also the answer NCLEX expects, so follow it unless your facility protocol or the proceduralist directs otherwise.
• Bleeding / hemothorax – uncommon but potentially life-threatening; the needle should pass just above a rib to avoid the intercostal neurovascular bundle. Monitor for increasing chest pain and hemodynamic instability
• Site infection – monitor the puncture site for erythema, warmth, drainage; reinforce sterile dressing care
• Vasovagal reaction – during or immediately after the procedure; manage with positioning (supine) and monitor for resolution

Medications

Treatment targets the underlying cause:

• Diuretics (furosemide, spironolactone): First-line for transudative effusions from CHF or cirrhosis. Reduce systemic fluid overload and venous hydrostatic pressure. Monitor potassium and renal function. See the heart failure nursing reference for full diuretic management details.
• Antibiotics: For parapneumonic effusions from bacterial pneumonia. Uncomplicated parapneumonic effusions resolve with antibiotic treatment alone. Complicated effusions (pH 7.2 or lower, positive Gram stain or culture, frank pus) need chest tube drainage in addition to antibiotics; loculated infected collections may also need intrapleural tPA plus DNase or surgery (MIST2). See the pneumonia nursing reference for antibiotic selection.
• Anticoagulation: For effusions secondary to pulmonary embolism – treatment of the PE typically resolves the effusion. See the pulmonary embolism nursing reference for anticoagulation protocols.
• Talc pleurodesis: Used for recurrent malignant effusions in patients whose lung re-expands. Talc is introduced into the pleural space (as a slurry via chest tube, or as poudrage at thoracoscopy) and causes an inflammatory reaction that fuses the pleural layers, obliterating the space and preventing re-accumulation. Pleuritic chest pain and fever are common in the first days afterward, so pain assessment and analgesia are key nursing priorities.
• Tunneled (indwelling) pleural catheters (TPC/IPC): An alternative to talc pleurodesis for malignant effusions; BTS 2023 favors an IPC over talc when more than 25% of the lung is non-expandable. In the TIME2 trial, breathlessness at 6 weeks did not differ significantly between an indwelling catheter and chest tube plus talc, and an Australian cohort found fewer inpatient days with catheters. A small catheter stays in place for drainage at home. BTS 2023 advises that drainage frequency follow the patient’s symptoms, except when the aim is pleurodesis in a lung that re-expands, when drainage should be as frequent as tolerated (daily). Nurses teach patients and caregivers the drainage technique and when to call.

NCLEX-style practice questions

Question 1

A nurse is assessing a patient admitted with dyspnea and right-sided chest pain. Auscultation reveals decreased breath sounds at the right base with dullness to percussion. Which diagnostic finding would be most consistent with a pleural effusion?

A) Hyperresonance on percussion of the right lower chest B) Blunting of the right costophrenic angle on chest X-ray C) Bilateral wheezing on auscultation D) Increased tactile fremitus over the right lower lobe

Answer: B – blunting of the right costophrenic angle

Rationale: Blunting of the costophrenic angle on CXR is the classic radiographic sign of pleural effusion, visible on the PA view at about 200 mL of fluid. Percussion produces dullness (not hyperresonance – option A) over fluid. Bilateral wheezing suggests airway obstruction, not pleural fluid. Tactile fremitus is decreased (not increased) when fluid lies between the lung and chest wall, dampening vibration transmission.

Question 2

A pleural fluid sample is sent to the lab after thoracentesis. The results show: pleural fluid protein 4.8 g/dL, serum protein 7.0 g/dL, pleural fluid LDH 280 units/L, serum LDH 320 units/L. Applying Light’s criteria, how should this effusion be classified?

A) Transudative – none of the criteria are met B) Exudative – the protein ratio meets criteria C) Exudative – the LDH ratio meets criteria D) Both B and C – two criteria are met

Answer: D – both protein ratio and LDH ratio criteria are met

Rationale: Light’s criterion 1: pleural:serum protein ratio = 4.8 ÷ 7.0 = 0.69 → exceeds the 0.5 threshold (exudate). Light’s criterion 2: pleural:serum LDH ratio = 280 ÷ 320 = 0.875 → exceeds the 0.6 threshold (exudate). An effusion is classified as exudative if ANY ONE criterion is met – in this case, two criteria are met. Only one criterion needs to be met to classify as exudative.

Question 3

A patient with congestive heart failure is found to have a bilateral pleural effusion. The nurse understands that this effusion is most likely which type, and what is the expected management?

A) Exudative; requires thoracentesis and antibiotics B) Transudative; will likely respond to diuretic therapy C) Exudative; requires talc pleurodesis D) Transudative; requires chest tube drainage

Answer: B – transudative; will likely respond to diuretic therapy

Rationale: CHF is the most common cause of transudative pleural effusion, driven by elevated pulmonary venous hydrostatic pressure. Transudates have low protein content and respond to treatment of the underlying hemodynamic cause – diuresis reduces venous pressure and allows fluid to be reabsorbed. Thoracentesis and chest tubes are reserved for symptomatic relief or complicated effusions. Talc pleurodesis is used for recurrent malignant effusions.

Question 4

A physician is preparing to perform a thoracentesis on a patient with a right-sided pleural effusion. What is the nurse’s most important action regarding patient positioning?

A) Place the patient in the left lateral decubitus position B) Position the patient supine with the right arm raised C) Sit the patient upright, leaning forward over a bedside table with arms supported D) Place the patient in the high-Fowler position with the right side elevated

Answer: C – seated upright, leaning forward over a bedside table

Rationale: The standard thoracentesis position is sitting upright with the patient leaning forward over a padded bedside table. This position widens the posterior intercostal spaces, drops the diaphragm, and opens the pleural space – maximizing access for needle insertion. The lateral decubitus position (A) is occasionally used for patients unable to sit, but the seated forward-leaning position is standard. Supine or high-Fowler positions do not adequately open the posterior pleural space.

Question 5

A thoracentesis has just been completed and 1,200 mL of straw-colored fluid was drained from a patient’s left pleural space. Thirty minutes later the patient develops sudden dyspnea, decreased breath sounds on the left, and a falling SpO2. What is the nurse’s priority action?

A) Administer a bronchodilator for bronchospasm B) Notify the provider immediately – pneumothorax is suspected C) Position the patient on the right side to drain remaining fluid D) Increase supplemental oxygen and document the findings

Answer: B – notify the provider immediately; pneumothorax is suspected

Rationale: Sudden dyspnea, decreased breath sounds on the ipsilateral side, and falling SpO2 following thoracentesis are the classic presentation of post-procedure pneumothorax – the most significant complication of thoracentesis. The nurse must notify the provider immediately for urgent evaluation and chest X-ray. Supplemental oxygen should be applied, but notification and evaluation take priority over documentation or repositioning. If tension pneumothorax is suspected (tracheal deviation, hemodynamic instability), this is a medical emergency requiring immediate intervention.

Question 6

During post-thoracentesis monitoring, the nurse notes the drained fluid volume was 1,800 mL. The patient now has a new cough, frothy sputum, and worsening dyspnea despite improved breath sounds bilaterally. What complication should the nurse suspect?

A) Recurrent pleural effusion B) Pulmonary embolism C) Reexpansion pulmonary edema D) Empyema

Answer: C – reexpansion pulmonary edema

Rationale: Reexpansion pulmonary edema is a rare but potentially fatal complication, most often when a chronically collapsed lung reexpands rapidly. As the lung reexpands, fluid shifts into the newly opened alveolar spaces, causing non-cardiogenic pulmonary edema, usually within the first hour. Signs include cough, frothy or pink-tinged sputum, and worsening hypoxemia after drainage – paradoxically worsening despite the effusion being drained. Studies disagree on how much drained volume itself drives the risk, but because RPE can be fatal, guidance such as the 2023 BTS clinical statement keeps a general limit of 1.5 L per attempt and stops drainage early if chest tightness, cough, or breathlessness develops. Draining 1,800 mL exceeded that limit, which makes RPE the leading suspect here.

Related references

• Pneumonia nursing: complete reference guide – pneumonia is the leading cause of exudative parapneumonic effusion
• Pulmonary embolism nursing reference – PE is one of the leading causes of exudative effusion
• ARDS nursing reference – effusions on CXR may complicate the interpretation of ARDS imaging
• Heart failure nursing reference – CHF is the most common cause of transudative pleural effusion
• Nursing lab values cheat sheet – reference for serum protein, LDH, albumin, and other labs used in effusion workup

This article is for educational purposes. Always apply clinical judgment and follow your institution’s evidence-based protocols when caring for patients with pleural effusion.

References

1. Light RW, MacGregor MI, Luchsinger PC, Ball WC Jr. Pleural effusions: the diagnostic separation of transudates and exudates. Annals of Internal Medicine. 1972;77(4):507–513. doi:10.7326/0003-4819-77-4-507
2. Light RW. Pleural effusion. New England Journal of Medicine. 2002;346(25):1971–1977. doi:10.1056/NEJMcp010731
3. Heffner JE, Brown LK, Barbieri CA. Diagnostic value of tests that discriminate between exudative and transudative pleural effusions. Chest. 1997;111(4):970–980. doi:10.1378/chest.111.4.970
4. Porcel JM, Light RW. Diagnostic approach to pleural effusion in adults. American Family Physician. 2006;73(7):1211–1220. PMID:16623208
5. Roberts ME, Rahman NM, Maskell NA, et al. British Thoracic Society Guideline for pleural disease. Thorax. 2023;78(Suppl 3):s1–s42. doi:10.1136/thorax-2022-219784 (supersedes the 2010 BTS pleural disease guideline)
6. Asciak R, Bedawi EO, Bhatnagar R, et al. British Thoracic Society Clinical Statement on pleural procedures. Thorax. 2023;78(Suppl 3):s43–s68. doi:10.1136/thorax-2022-219371
7. Davies HE, Mishra EK, Kahan BC, et al. Effect of an indwelling pleural catheter vs chest tube and talc pleurodesis for relieving dyspnea in patients with malignant pleural effusion: the TIME2 randomized controlled trial. JAMA. 2012;307(22):2383–2389. doi:10.1001/jama.2012.5535
8. Fysh ETH, Waterer GW, Kendall PA, et al. Indwelling pleural catheters reduce inpatient days over pleurodesis for malignant pleural effusion. Chest. 2012;142(2):394–400. doi:10.1378/chest.11-2657
9. Rahman NM, Maskell NA, West A, et al. Intrapleural use of tissue plasminogen activator and DNase in pleural infection (MIST2). New England Journal of Medicine. 2011;365(6):518–526. doi:10.1056/NEJMoa1012740
10. Light RW. Parapneumonic effusions and empyema. Proceedings of the American Thoracic Society. 2006;3(1):75–80. doi:10.1513/pats.200510-113JH
11. Feller-Kopman D, Berkowitz D, Boiselle P, Ernst A. Large-volume thoracentesis and the risk of reexpansion pulmonary edema. Annals of Thoracic Surgery. 2007;84(5):1656–1661. doi:10.1016/j.athoracsur.2007.06.038
12. Diacon AH, Brutsche MH, Solèr M. Accuracy of pleural puncture sites: a prospective comparison of clinical examination with ultrasound. Chest. 2003;123(2):436–441. doi:10.1378/chest.123.2.436
13. Gordon CE, Feller-Kopman D, Balk EM, Smetana GW. Pneumothorax following thoracentesis: a systematic review and meta-analysis. Archives of Internal Medicine. 2010;170(4):332–339. doi:10.1001/archinternmed.2009.548
14. Ault MJ, Rosen BT, Scher J, Feinglass J, Barsuk JH. Thoracentesis outcomes: a 12-year experience. Thorax. 2015;70(2):127–132. doi:10.1136/thoraxjnl-2014-206114
15. Blackmore CC, Black WC, Dallas RV, Crow HC. Pleural fluid volume estimation: a chest radiograph prediction rule. Academic Radiology. 1996;3(2):103–109. doi:10.1016/S1076-6332(05)80373-3
16. Porcel JM, Vives M. Etiology and pleural fluid characteristics of large and massive effusions. Chest. 2003;124(3):978–983. doi:10.1378/chest.124.3.978
17. Sonnenblick M, Melzer E, Rosin AJ. Body positional effect on gas exchange in unilateral pleural effusion. Chest. 1983;83(5):784–786. doi:10.1378/chest.83.5.784
18. O’Driscoll BR, Howard LS, Earis J, Mak V; BTS Emergency Oxygen Guideline Group. BTS guideline for oxygen use in adults in healthcare and emergency settings. Thorax. 2017;72(Suppl 1):ii1–ii90. doi:10.1136/thoraxjnl-2016-209729
19. Hooper C, Lee YCG, Maskell N; BTS Pleural Guideline Group. Investigation of a unilateral pleural effusion in adults: British Thoracic Society pleural disease guideline 2010. Thorax. 2010;65(Suppl 2):ii4–ii17. doi:10.1136/thx.2010.136978 (superseded by the 2023 guideline; retained for historical reference)